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Volume: 9, Issue: 8, August, 2019
DOI: 10.7324/JAPS.2019.90803



Research Article

Synthesis and anticancer potential of aminomethyl derivatives of methyl-substituted asymmetrical curcumin mono-carbonyl

Arini Kurnia1, Fadlina Chany Saputri2, Hayun Hayun1

  Author Affiliations


Abstract

A series of new aminomethyl derivatives of methyl-substituted asymmetrical curcumin mono-carbonyl was synthesized and evaluated for their anticancer potential by means of cytotoxicity and selectivity determination against MCF-7, WiDr, Hela, A549, PLC/PRF/5, and Chang Liver cells lines using the methyl thiazolyl tetrazolium proliferation assay method. All the synthesized compounds (3a–f) exhibited high cytotoxic against WiDr cells lines, but only 3a–e had high cytotoxic against MCF-7 cells lines, and only 3b showed high cytotoxic against HeLa, A549, and PLC/PRF/5 cell lines. However, 3b and 3c exhibited high cytotoxic against Chang Liver (normal liver) cells lines. Further evaluations showed that compounds 3d, 3e, and 3f exhibited a potent and selective cytotoxic agent (IC50 = 5.70, 5.55, and 2.97 μM) against WiDr (colorectal carcinoma) cells lines with selectivity index (SI) = 4.43, 2.69, and 2.04, respectively. The compounds performed better cytotoxic activity than curcumin and 5-fluorouracil (IC50 = 8.29 and >100 μM and SI = 1.28 and

Keywords:

Curcumin, asymmetrical curcumin mono-carbonyl, aminomethyl derivatives, anticancer potential, cytotoxicity, selectivity index.



Citation: Kurnia A, Saputri FC, Hayun H. Synthesis and anticancer potential of aminomethyl derivatives of methyl-substituted asymmetrical curcumin mono-carbonyl. J Appl Pharm Sci, 2019; 9(08):018–024.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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