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Volume: 8, Issue: 10, October, 2018
DOI: 10.7324/JAPS.2018.81012



Research Article

Anti-hypercholesterolemic effect of unripe Musa paradisiaca products on hypercholesterolemia-induced rats

Tayo Alex Adekiya1, Sidiqat Abike Shodehinde2, Raphael Taiwo Aruleba1

  Author Affiliations


Abstract

Hypercholesterolemia is a metabolic disorder caused by an increase in the concentrations level of plasma low-density lipoprotein (LDL) cholesterol. It has been implicated as a primary risk factor related to the pathogenesis of atherosclerosis or coronary heart disease, ischemic heart disease or cardiovascular disease, including myocardial infarction. Musa paradisiaca (M. paradisiaca) is a remarkable medicinal plant. Its potential in the management of diabetes mellitus as well as in nephropathy and myocardial infarction in animal models has been reported. This present study aimed at examining the effects of unripe plantain (M. paradisiaca) products (elastic pastry and roasted plantain) commonly known as amala and boli, respectively, in Nigeria on hypercholesterolemia-induced rats. The anti-hypercholesterolemic activity of these products was studied in 1% cholesterol-induced rats. Thirty-six rats were randomly divided into six groups and fed for 21 days with different plantain-supplemented diets. The hypercholesterolemic potential of the products was evaluated by measuring biochemical parameters, such as plasma lipid peroxidation (LPO), plasma lipid profiles, and plasma liver biomarkers. Results revealed that the inclusion of “amala” and “boli” in hypercholesterolemic rat diets not only significantly decreased the high levels of plasma LPO, total cholesterol, triglyceride, LDL cholesterol, and plasma liver biomarkers but also increased the activities of high-density lipoprotein cholesterol in the plasma of treated animals as compared with the control. This study, therefore, suggests that unripe plantain products amala and boli confer protective effects against various biochemical changes in experimentally-induced hypercholesterolemic animal models.

Keywords:

Amala, boli, hypercholesterolemia, liver biomarkers, Musa paradisiaca.



Citation: Adekiya TA, Shodehinde SA, Aruleba RT. Antihypercholesterolemic effect of unripe Musa paradisiaca products on hypercholesterolemia-induced rats. J App Pharm Sci, 2018; 8(10): 090-097.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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