Volume: 8, Issue: 10, October, 2018
Anti-hypercholesterolemic effect of unripe Musa paradisiaca products on hypercholesterolemia-induced ratsAuthor Affiliations
Hypercholesterolemia is a metabolic disorder caused by an increase in the concentrations level of plasma low-density lipoprotein (LDL) cholesterol. It has been implicated as a primary risk factor related to the pathogenesis of atherosclerosis or coronary heart disease, ischemic heart disease or cardiovascular disease, including myocardial infarction. Musa paradisiaca (M. paradisiaca) is a remarkable medicinal plant. Its potential in the management of diabetes mellitus as well as in nephropathy and myocardial infarction in animal models has been reported. This present study aimed at examining the effects of unripe plantain (M. paradisiaca) products (elastic pastry and roasted plantain) commonly known as amala and boli, respectively, in Nigeria on hypercholesterolemia-induced rats. The anti-hypercholesterolemic activity of these products was studied in 1% cholesterol-induced rats. Thirty-six rats were randomly divided into six groups and fed for 21 days with different plantain-supplemented diets. The hypercholesterolemic potential of the products was evaluated by measuring biochemical parameters, such as plasma lipid peroxidation (LPO), plasma lipid profiles, and plasma liver biomarkers. Results revealed that the inclusion of “amala” and “boli” in hypercholesterolemic rat diets not only significantly decreased the high levels of plasma LPO, total cholesterol, triglyceride, LDL cholesterol, and plasma liver biomarkers but also increased the activities of high-density lipoprotein cholesterol in the plasma of treated animals as compared with the control. This study, therefore, suggests that unripe plantain products amala and boli confer protective effects against various biochemical changes in experimentally-induced hypercholesterolemic animal models.
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