Research Article | Volume: 8, Issue: 8, August, 2018

Fabrication of Buccal Dissolving Tetrahydro Curcumin Loaded Polyvidone Fiber Mat: Synthesis, Characterization, and In Vitro Evaluations

Ravikumar Rramaswamy Ganesh Mani Hyun Tae Jang   

Open Access   

Published:  Aug 31, 2018

DOI: 10.7324/JAPS.2018.8804
Abstract

A simple high molecular weight polyvidone (PVP) with tetrahydro curcumin (THC) loaded nanofiber was prepared and in-vitro dissolution was evaluated. Various polymeric concentration solution of PVP was prepared, from which 10% w/v PVP solution was used to load 10% w/w THC. The morphology of the prepared nanofibers was evaluated using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and ultraviolet-visible (UV-Vis) spectroscopy. The prepared mat released around 91% of the loaded THC within the first 5 minutes of the dissolution evaluation, which might be suitable for a buccal delivery system with a higher dissolution rate.


Keyword:     Polyvinylpyrrolidone Nanofibers Tetrahydro curcumin Electrospinning In vitro evaluations.


Citation:

Rramaswamy R, Mani G, Jang HT. Fabrication of Buccal Dissolving Tetrahydro Curcumin Loaded Polyvidone Fiber Mat: Synthesis, Characterization, and In Vitro Evaluations. J App Pharm Sci, 2018; 8(08): 026-031.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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