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Volume: 9, Issue: 2, February, 2019
DOI: 10.7324/JAPS.2019.90207

Research Article

Recycling of expired paracetamol-containing drugs as source of useful reagents for an organic synthesis

Inna Puzanova1, Andrii Lozynskyi2, Lilia Lesyk3, Bohdan Hromovyk1, Roman Lesyk2

  Author Affiliations


All types of pharmaceutical waste negatively impact on the environment and human health and require special methods of utilization. In the current study, it is described that the elaboration of utilization methods of one of the most commonly used medicines as paracetamol of various brands and forms on the example of expired and substandard drugs based on acid hydrolysis providing 4-aminophenol with 16%–87% yields. The actuality of obtaining the 4-aminophenol derivatives revealed by their findings in the structure of many biologically active compounds with anticancer, antimicrobial, antioxidant, and cardiovascular activities. In addition, it has been demonstrated that the chemical transformation of paracetamol in capsule and tablet dosage forms providing N-[4-(benzyloxy)phenyl] acetamide as a useful reagent in an organic synthesis in the reaction with benzyl chloride in an alkaline medium. The structures of obtained products and purity were established on the basis of mass spectrometry (LCMS+) techniques. As a result, the simple procedure from moderate to good yield is an important feature of paracetamol-containing drug utilization as a source of different useful reagents for an organic synthesis and industrial production.


Paracetamol, utilization, 4-aminophenol, N-[4- (benzyloxy)phenyl] acetamide, hydrolysis

Citation: Puzanova I, Lozynskyi A, Lesyk L, Hromovyk B, Lesyk R. Recycling of expired paracetamol-containing drugs as source of useful reagents for an organic synthesis. J Appl Pharm Sci, 2019; 9(02):052–056.

Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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