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Volume: 3, Issue: 6, June, 2013
DOI: 10.7324/JAPS.2013.3609



Research Article

Synthesis and Characterization of biodegradable Poly (Vinyl caprolactam) grafted on to sodium alginate and its microgels for controlled release studies of an anticancer drug


K. Madhusudana Rao1, K.S.V. Krishna Rao2, P. Sudhakar1, K. Chowdoji Rao3 and M.C.S. Subha1

  Author Affiliations


Abstract

Biodegradable sodium alginate-g-poly (vinyl caprolactam) synthesized by graft copolymerization of N-vinyl caprolactam (VCL) on to sodium alginate (NaAlg) via free radical initiation mechanism using a redox initiation system. Grafting (%), efficiency (%), and conversion (%) were all found to depend on the content of potassium persulfate (KPS), VCL reaction temperature and time. The maximum % of grafting was ascertained to be 251 at the optimum conditions of 65 oC reaction temperature, 180 min of reaction time, 1.1098X10-3 mol of KPS and 7.1844X10-3 mol of VCL. Evidence of graft copolymerization was obtained by fouriertransform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Further, graft copolymer was used for preparation of microgels (MGs) using Ca+2 as a crosslinking agent. SEM results showed that the MGs are spherical in structure with smooth surface. The effects of pH and temperature on the swelling behaviour of MGs were studied and ascertained that they were sensitive to both pH and temperature. 5-FU drug was successfully loaded in to these MGs and encapsulation efficiency was found 84%. The release of 5-FU was systematically investigated as a function of temperature, pH, amount of crosslinker and % of drug loading concentration. The results indicate that the responsive MGs have the potential to be used as an effective pH and temperature controlled delivery of 5-FU for more than 12 h.

Keywords:

Graft copolymer, microgels, pH and temperature sensitive, drug release.



Citation: K. Madhusudana Rao, K.S.V. Krishna Rao, P. Sudhakar, K. Chowdoji rao and M.C.S. Subha., Synthesis and Characterization of biodegradable Poly (Vinyl caprolactam) grafted on to sodium alginate and its microgels for controlled release studies of an anticancer drug. J App Pharm Sci, 2013; 3 (06): 061-069.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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