Home >Archive

Volume: 2 Issue: 7, July 2012
DOI: 10.7324/JAPS.2012.2701



Review Article

The Effect of Curcumin and Tocotrienol on the Development of Eye Disease


Mohanad Rahman Alwan, Sami Abdo Radman Al-Dubai, Redhwan Ahmed Mohammed Al-Naggar, Mohammed Faez Baobaid, Mustafa Fadil Mohammed, Mahfoudh Abdulghani

  Author Affiliations


Abstract

There is growing evidence that inflammation may be one of the causative factors of many chronic diseases especially which is related to eyes such as cataract, age-related macular degeneration and uveitis. Several cytokines such as IL-1,IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of chronic diseases. Anti-cytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Few animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent chronic eye disease in rat models by suppressing IL-1 and IL-6. Free radicals are known to activate transcription factor NFκB which leads to the production of bone re-sorbing cytokines. Tocotrienol, a potent antioxidant, may be able to neutralize free radicals before they could activate NFκB, therefore suppressing cytokine production and inflammatory reaction. Curcumin is widely reported to have potent anti-oxidative, anti-inflammatory and anticarcinogenic effects. The anti-inflammatory action of curcumin seems to be closely related to inhibition of TNF-α and other inflammatory cytokines production and suppression of NF-κB activation by blocking phosphorylation of inhibitory factor I-kappa B kinase (IκB) Tocotrienol and curcumin have also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions of the these studied, tocotrienol seemed to be better than tocopherols in terms of it sability to suppress inflammation induced by cytokines.

Keywords:

Curcumin, Tocotrienol, Eye Disease, Inflammation.



Citation:


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

Article Metrics