Research Article | Volume : 2 Issue : 3, March 2012

In-Vitro Antioxidant and Cytotoxicity Screening of Different Bark Extracts of Aegle Marmelos L

Kaise Hamid,  Farhana Diba,  Kaniz Fatima Urmi,  Muhammad Erfan Uddin,  Fatema Tuz Zohera,  Md. Razibul Habib   
Kaise Hamid1, Farhana Diba1, Kaniz Fatima Urmi2, Muhammad Erfan Uddin3, Fatema Tuz Zohera2, Md. Razibul Habib1

1Department of Pharmacy, East West University, Dhaka, Bangladesh.

2Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh.

3Department of Pharmacy, International Islamic University Chittagong, Banglade.

Open Access    DOI: 10.7324/JAPS.2012.2315

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Abstract

The present study was designed to investigate the antioxidant and cytotoxic activity of the methanol, ethyl acetate and n-hexane extracts of bark of Aegle marmelos. The antioxidant properties was assessed by using 1, 1-diphenyl-2- picrylhydrazyl radical (DPPH) and Nitric Oxide (NO) scavenging capacity. The methanolic, ethyl acetate and n-hexane bark extracts ofAegle marmelos showed potential DPPH free radical scavenging activity having IC50 values of 37.056 μg/ml, 43.379 μg/ml and 66.180 μg/ml respectively compared with the IC50 value of Ascorbic acid 33.447 μg/ml. The Ethyl acetate extract of Aegle marmelos displayed excellent antioxidant activity in nitric oxide (NO) scavenging capacity assay with IC50 value of 28.377 μg/ml compared with the standard ascorbic acid, IC50 value of 22.175 μg/ml. The cytotoxicity assay was performed by applying brine shrimp lethality bioassay method. Among all the fractions, n-hexane extract shown profound cytotoxic activity with LC50 value of 4.482 μg/ml that was followed by methanolic and ethyl acetate having LC50 values of 5.278 and 5.278 μg/ml respectively in comparison with the standard vincristine sulfate with LC50 value of 3.364 μg/ml. The findings of the present study suggest that the extracts from Aegle marmelos bark have potential cytotoxicity and antioxidant effects.


Keyword:     Aegle marmelosCytotoxicityDPPHAntioxidantScavenging.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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