Research Article | Volume : 2 Issue : 2, February 2012

Effect of Clobetasol Propionate and Clobetasol Butyrate with Biopolymer on Skin Inflammatory Model in Wistar Rats

Bairy KL,  Pawan kumar A.V,  Chandrashekar BR,  Avinash M Holla,  Rockson Christopher,  Purnima Sirigiri,  Satish Kumar MC   
Bairy KL1, Pawan kumar A.V3, Chandrashekar BR3, Avinash M Holla3, Rockson Christopher3, Purnima Sirigiri3, Satish Kumar MC2

1Kasturba Medical College, Manipal University, Manipal, Karnataka- 576104, India.

2Kasturba Medical College, Manipal University, Manipal, Karnataka- 576104, India.

3Kasturba Medical College, Manipal University, Manipal, Karnataka576104, India.

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Abstract

The treatment of chronic inflammatory skin conditions are not satisfactory. There is a need for better antiflammatory drugs for these conditions. This study was done to compare the efficacy of biopolymer based formulations of clobetasol propionate and clobetasol butyrate with commercially available Preparations of clobetasol in animal models of superficial skin inflammation in rats. The croton oil ear edema in rats was the chronic inflammatory model used in this study. In this model, the animals treated with clobetasol propionate and clobetasol butyrate with biopolymer showed a significant decrease in inflammation as compared to commercially available preparations of clobetasol(Tenovate and Eumosone).


Keyword:     Atopic dermatitis biopolymer clobetasol propionate clobetasol.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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