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Volume: 9, Issue: 8, August, 2019
DOI: 10.7324/JAPS.2019.90816



Review Article

Chalcones bearing N, O, and S-heterocycles: Recent notes on their biological significances

Bayu Ardiansah

  Author Affiliations


Abstract

Because of its relatively easy synthesis, chalcone skeleton has been as a point of interest for organic and medicinal chemists from research groups worldwide. Chalcone scaffold constitutes the core of some interesting biologically active natural products. Chalcone derivatives are among feasible potent active agents, such as anticancer, antibacterial, antifungal, antileishmanial, antimalarial, and antiviral. Due to the knowledge of heterocyclic chemistry, recently chalcones bearing heterocyclic moieties have been synthesized and biologically investigated for specific target of diseases. The current review focuses on the latest application of chalcones integrated with N, O, and S-heterocyclic system and their wide spectrum of biological performance during 10 years (2010–2019). The results reported in the review indicate that many chalcone-heterocycle hybrids may be useful as future drug candidates due to their comparable or higher activity than that of the standards.

Keywords:

Chalcones, heterocyclic, N, O, S-heteroaromatic, biological activity, potent drugs.



Citation: Ardiansah B. Chalcones bearing N, O, and S-heterocycles: Recent notes on their biological significances. J Appl Pharm Sci, 2019; 9(08):117–129


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

Ahmadi S, Mardinia F, Azimi N, Qomi M, Balali E. Prediction of chalcone derivative cytotoxicity activity against MCF-7 human breast cancer cell by Monte Carlo method. J Mol Struct, 2019; 1181: 305-11. https://doi.org/10.1016/j.molstruc.2018.12.089

Avila-Villarreal G, Hernández-Abreu O, Hidalgo-Figueroa S, Navarrete-Vázquez G, Escalante-Erosa F, Pena-Rodríguez LM, Villalobos- Molina R, Estrada-Soto S.Antihypertensive and vasorelaxant effects of dihydrospinochalcone-A isolated from Lonchocarpus xuul Lundell by NO production: computational and ex vivo approaches. Phytomedicine, 2013; 20(14):1241-6. https://doi.org/10.1016/j.phymed.2013.06.011

Ayman M, El-Messery SM, Habib EE, Al-Rashood ST, Almehizia AA, Alkahtani HM, Hassan GS. Targeting microbial resistance: synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives. Bioorg Chem, 2019; 85: 282-92. https://doi.org/10.1016/j.bioorg.2019.01.001

Baldisserotto A, Demurtas M, Lampronti I, Moi D, Balboni G, Vertuani S, Manfredini S, Onnis V. Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity. Eur J Med Chem, 2018; 156:118-25. https://doi.org/10.1016/j.ejmech.2018.07.001

Bandgar BP, Jalde SS, Adsul LK, Shringare SN, Lonikar SV, Gacche RN, Dhole NA, Nile SH, Shirfule AL. Synthesis of new olefin chalcone derivatives as antitumor, antioxidant and antimicrobial agents. Med Chem Res, 2012; 21(12):4512-22. https://doi.org/10.1007/s00044-012-9979-z

Bonakdar APS, Vafaei F, Farokhpour M, Esfahani MHN, Massah AR. Synthesis and anticancer activity assay of novel chalcone-sulfonamide derivatives. Iran J Pharm Res, 2017; 16(2):565-8.

Celik F, Unver Y, Barut B, Ozel A, Sancak K. Synthesis, characterization and biological activities of new symmetric bis-1,2,3- triazoles with click chemistry. Med Chem, 2018; 14(3):230-41. https://doi.org/10.2174/1573406413666171120165226

Chandra Sekhar D, Tejeswara Rao A, Venkata Rao DV, Lav Kumar U, Anjali J. Synthesis and anticancer/antibacterial activity of compounds containing thiophene ring linked to a chalcone derivatives. Chem Biol Interface, 2018; 8(2):94-105.

Chen Z, Li P, Hu D, Dong L, Pan J, Luo L, Zhang W, Xue W, Jin L, Song B. Synthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties. Arab J Chem, 2015; Article in press DOI of the published paper: http://dx.doi. org/10.1016/j.arabjc.2015.05.003 https://doi.org/10.1016/j.arabjc.2015.05.003

Coskun D, Erkisa M, Ulukaya E, Coskun MF, Ari F. Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity. 2017; 136: 212-222. https://doi.org/10.1016/j.ejmech.2017.05.017

Desai V, Desai S, Gaonkar SN, Palyekar U, Joshi SD, Dixit SK. Novel quinoxalinyl chalcone hybrid scaffolds as enoyl ACP reductase inhibitors: synthesis, molecular docking and biological evaluation. Bioorg Med Chem Lett, 2017; 27:2174-80. https://doi.org/10.1016/j.bmcl.2017.03.059

Díaz-Carillo JT, Díaz-Camacho SP, Delgado-Vargas F, Rivero IA, López-Angulo G, Sarmiento-Sánchez JI, Montes-Avila J. Synthesis of leading chalcones with high antiparasitic, against Hymenolepis nana, and antioxidant activities. Braz J Pharm Sci, 2018; 54(3):1-13. https://doi.org/10.1590/s2175-97902018000317343

Dumontet C, Beck G, Gardebien F, Haudecoeur R, Mathé D, Matera E-L, Tourette A, Mattei E, Esmenjaud J, Boyère C, Nurisso A, Peuchmaur M, Pérès B, Bouchaud G, Magnan A, Monneret G, Boumendjel A. Piperidinyl-embedded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models. Eur J Med Chem, 2018; 158:405-13. https://doi.org/10.1016/j.ejmech.2018.09.033

El-Gamal MI, Abdel-Maksoud MS, Gamal El-Din MM, Shin JS, Lee KT, Yoo KH, Oh CH. Synthesis, in vitro antiproliferative and antiinflammatory activities, and kinase inhibitory effects of new 1,3,4-triarylpyrazole derivatives. Anticancer Agents Med Chem, 2017; 17(1):75-84. https://doi.org/10.2174/1871520616666160620074534

Espinoza-Hicks JC, Chacon-Vargas KF, Hernandez-Rivera JL, Nogueda-Torres B, Tamariz J, Shancez-Torres LE, Camacho-Dávila A. Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: design, synthesis and evaluation. Eur J Med Chem, 2019; 167:402- 13. https://doi.org/10.1016/j.ejmech.2019.02.028

Fogaça TB, Martins RM, Begnini KR, Carapina C, Ritter M, de Pereira CMP, Seixas FK, Collares T. Apoptotic effect of chalcone derivatives of 2-acetylthiophene in human breast cancer cells. Pharmacol Rep, 2017; 69:156-61. https://doi.org/10.1016/j.pharep.2016.10.003

Foroumadi A, Emami S, Sorkhi M, Nakhjiri M, Nazarian Z, Heydari S, Ardestani SK, Poorrajab F, Shafiee A. Chromene-based synthetic chalcones as potent antileishmanial agents: synthesis and biological activity. Chem Biol Drug Des, 2010; 75:590-6. https://doi.org/10.1111/j.1747-0285.2010.00959.x

Gan X, Wang Y, Hu D, Song B. Design, synthesis, and antiviral activity of novel chalcone derivatives containing a purine moiety. Chin J Chem, 2017; 35:665-72. https://doi.org/10.1002/cjoc.201600568

Han X, Peng B, Xiao B-B, Cao S-L, Yang C-R, Wang W-Z, Wang FC, Li HY, Yuan XL, Shi R, Liao J, Wang H, Li J, Xu X. Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents. Eur J Med Chem, 2019; 162:586-601. https://doi.org/10.1016/j.ejmech.2018.11.034

Hayat F, Moseley E, Salahuddin A, Van Zyl RL, Azam A. Antiprotozoal activity of chloroquinoline based chalcones. Eur J Med Chem, 2011; 46(5):1897-905. https://doi.org/10.1016/j.ejmech.2011.02.004

Herbst, RS. Erlotinib (Tarceva): an update on the clinical trial program. Semin Oncol, 2003; 30:34-46. https://doi.org/10.1016/S0093-7754(03)70013-X

Insuasty B, Ramírez J, Becerra D, Echeverry C, Quiroga J, Abonia R, Robledo SM, Vélez ID, Upegui Y, Muñoz JA, Ospina V, Nogueras M, Cobo J. An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents. Eur J Med Chem, 2015; 93:401-13. https://doi.org/10.1016/j.ejmech.2015.02.040

Janaki P, Sekar KG, Thirunarayanan G. Synthesis, spectral correlation and insect antifeedant activities of some 2-benzimidazole chalcones. J Saudi Chem Soc, 2016; 20:58-68. https://doi.org/10.1016/j.jscs.2012.11.013

Kalaria PN, Karad SC, Raval DK. A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery. Eur J Med Chem, 2018; 158:917-36. https://doi.org/10.1016/j.ejmech.2018.08.040

Kim H-G, Oh H-J, Ko J-H, Song HS, Lee Y-G, Kang SC, Lee DY, Baek NI. Lanceoleins A-G, hydroxychalcones, from the flowers of Coreopsis lanceolata and their chemopreventive effects against human colon cancer cells. Bioorg Chem, 2019; 85:274-81. https://doi.org/10.1016/j.bioorg.2019.01.003

Kucerova-Chlupacova M, Kunes J, Buchta V, Vejsova M, Opletalova V. Novel pyrazine analogs of chalcones: synthesis and evaluation of their antifungal and antimycobacterial activity. Molecules, 2015; 20:1104-17. https://doi.org/10.3390/molecules20011104

Kumari S, Paliwal SK, Chauhan R. An improved protocol for the synthesis of chalcones containing pyrazole with potential antimicrobial and antioxidant activity. Curr Bioactive Comp, 2018; 14:39-47. https://doi.org/10.2174/1573407212666161101152735

Kuthyala S, Nagaraja GK, Sheik S, Hanumanthappa M, Kumar SM. Synthesis of imidazo [1,2-a]pyridine-chalcones as potent inhibitors against A549 cell line and their crystal studies. J Mol Struct, 2019; 1177:381-90. https://doi.org/10.1016/j.molstruc.2018.09.087

Lei C, Zhang L-B, Yang J, Gao L-X, Li J-Y, Li J, Hou A-J. Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata. Tetrahedron Lett, 2016; 57(49):5475-8. https://doi.org/10.1016/j.tetlet.2016.10.090

Li P-H, Jiang H, Zhang W-J, Li Y-L, Zhao M-C, Zhou W, Zhang LY, Tang YD, Dong CZ, Huang ZS, Chen HX, Du ZY. Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers. Eur J Med Chem, 2018; 145:498-510. https://doi.org/10.1016/j.ejmech.2018.01.010

Lokesh BVS, Prasad YR, Shaik AB. Synthesis and biological activity of novel 2,5-dichloro-3-acetylthiophene chalcone derivatives. Indian J Pharm Ed Res, 2017; 51(4S):S679-90. https://doi.org/10.5530/ijper.51.4s.99

Madhavi S, Sreenivasulu R, Yazala JP, Raju RR. Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents. Saudi Pharm J, 2017; 25:275-9. https://doi.org/10.1016/j.jsps.2016.06.005

Mathew B, Suresh J, Mathew GE, Haridas A, Suresh G, Sabreena P. Synthesis, ADME studies, toxicity estimation, and exploration of molecular recognition of thiophene based chalcones towards monoamine oxidase-A and B. Beni-Suef Univ J Basic Appl Sci, 2016; 5:396-401. https://doi.org/10.1016/j.bjbas.2015.06.003

Ming LS, Jamalis J, Al-Maqtari HM, Rosli MM, Sankaranarayanan M, Chander S, Fun H-K. Synthesis, characterization, antifungal activities and crystal structure of thiophene-based heterocyclic chalcones. Chem Data Collections, 2017; 9-10:104-13. https://doi.org/10.1016/j.cdc.2017.04.004

Morales PAC, Dugarte CS, Amaro Luis JM. 2',3,4-trihydroxychalcone, phloretin and calomelanone from Stevia lucida. The first chalcones reported in Stevia genus. Biochem Syst Ecol, 2018; 77:57-60. https://doi.org/10.1016/j.bse.2018.02.005

Mphahlele MJ, Maluleka MM, Parbhoo N, Malindisa ST. Synthesis, evaluation for cytotoxicity and molecular docking studies of benzo[c]furan-chalcones for potential to inhibit tubulin polymerization and/ or EGFR-tyrosine kinase phosphorylation. Int J Mol Sci, 2018; 19:2552. https://doi.org/10.3390/ijms19092552

Murphy M, Stordal B. Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review. Drug Resist Update, 2011; 14: 177-90. https://doi.org/10.1016/j.drup.2011.02.004

Naganagowda G, Thamyongkit P, Petsom A. Synthesis and antimicrobial activities of benzothiophene derivatives. J Chil Chem Soc, 2012; 57(1):1043-7. https://doi.org/10.4067/S0717-97072012000100019

Niu H, Wang W, Li J, Lei Y, Zhao Y, Yang W, Zhao C, Lin B, Song S, Wang S. A novel structural class of coumarin-chalcone fibrates as PPARα/γ agonists with potent antioxidant activities: design, synthesis, biological evaluation and molecular docking studies. Eur J Med Chem, 2017; 138:212-20. https://doi.org/10.1016/j.ejmech.2017.06.033

Osorio TM, Monache FD, Chiaradia LD, Mascarello A, Stumpf TR, Zanetti CR, Silveira, DB, Barardi CRM, Smânia EFA, Viancelli A, Garcia LAT, Yunes RA, Nunes RJ, Smânia A. Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett, 2012; 22(1):225-30. https://doi.org/10.1016/j.bmcl.2011.11.059

Padhy GK, Panda J, Behera AK. Synthesis and characterization of novel benzimidazole chalcones as antibacterial agents. Der Pharma Chemica, 2016; 8(13):235-41.

Park S, Kim EH, Kim J, Kim SH, Kim I. Biological evaluation of indolizine-chalcone hybrids as new anticancer agents. Eur J Med Chem, 2018; 144:435-43. https://doi.org/10.1016/j.ejmech.2017.12.056

Pinto E, Neves H, Hrimpeng K, Silva A-F, Begouin A, Lopes G, Queiroz MJ. Antimicrobial activity and mechanism of action of new N-heteroaryl-1H-(benz)imidazoles. Mini-Rev Med Chem, 2014; 14(11):941-52. https://doi.org/10.2174/1389557514666141029225524

Pradip S, Khushboo M, Anand C, Devanshi G, Sudha S, Sweta K, Abhay C, Meena K. Virucidal activity of newly synthesized chalcone derivatives against H1N1 virus supported by molecular docking and membrane interaction studies. J Antivir Antiretrovir, 2016; 8(2):79-89. https://doi.org/10.4172/jaa.1000139

Ritter M, Martins RM, Rosa SA, Malavolta JL, Lund RG, Flores AFC, Pereira CMP. Green synthesis of chalcones and microbiological evaluation. J Braz Chem Soc, 2015; 26(6):1201-10. https://doi.org/10.5935/0103-5053.20150084

Romero-Parra J, Mella-Raipán J, Palmieri V, Allarà M, Torres MJ, Pessoa-Mahana H, Iturriaga-Vásquez P, Escobar R, Faúndez M, Di Marzo V, Pessoa-Mahana CD. Synthesis, binding assays, cytotoxic activity and docking tudies of benzimidazole and benzothiophene derivatives with selective affinitiy for the CB2 cannabinoid receptor. Eur J Med Chem, 2016; 124:17-35. https://doi.org/10.1016/j.ejmech.2016.08.005

Rücker H, Al-Rifai N, Rascle A, Gottfried E, Brodziak-Jarosz L, Gerhäuser C, Dick TP, Amslinger S. Enhancing anti-inflammatory activity of chalcones by tuning the Michael acceptor site. Org Biomol Chem, 2015; 13(10):3040-7. https://doi.org/10.1039/C4OB02301C

Salae A-W, Chairerk O, Sukkoet P, Chairat T, Prawat U, Tuntiwachwuttikul P, Chalermglin P, Ruchirawat S. Antiplasmodial dimeric chalcone derivatives from the roots of Uvaria siamensis. Phytochem, 2017; 135:135-43. https://doi.org/10.1016/j.phytochem.2016.12.009

Saleh SS, AL-Salihi SS, Mohammed IA. Biological activity study for some heterocyclic compounds and their impact on the gram positive and negative bacteria. Energy Procedia, 2019; 157:296-306. https://doi.org/10.1016/j.egypro.2018.11.194

Sashidhara KV, Avula SR, Doharey PK, Singh LR, Balaramnavar VM, Gupta J, Misra-Bhattacharya S, Rathaur S, Saxena AK, Saxena JK. Designing, synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: in vitro validation and docking studies. Eur J Med Chem, 2015; 103:418-28. https://doi.org/10.1016/j.ejmech.2015.09.004

Sashidhara KV, Kumar A, Kumar M, Sarkar J, Sinha S. Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents. Bioorg Med Chem Lett, 2010; 20:7205-11. https://doi.org/10.1016/j.bmcl.2010.10.116

Sashidhara KV, Modukuri RK, Jadiya P, Dodda RP, Kumar M, Sridhar B, Kumar V, Haque R, Siddiqi MI, Nazir A. Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. ChemMedChem, 2014; 9:2671-84. https://doi.org/10.1002/cmdc.201402291

Sasidharan R, Baek SC, Manju SL, Kim H, Mathew B. Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors. Biomed Pharmacother, 2018; 106:8-13. https://doi.org/10.1016/j.biopha.2018.06.064

Shankaraiah N, Siraj KP, Nekkanti S, Srinivasulu V, Sharma P, Senwar KR, Sathish M, Vishnuvardhan MVPS, Ramakrishna S, Jadala C, Nagesh N, Kamal A. DNA-binding affinity and anticancer activity of β-carboline-chalcone conjugates as potential DNA intercalators: molecular modelling and synthesis. Bioorg Chem, 2015; 59:130-9. https://doi.org/10.1016/j.bioorg.2015.02.007

Shukla P, Satyanarayana M, Verma PC, Tiwari J, Dwivedi AP, Srivastava R, Rehuja N, Tamrakar AK, Dwivedi AK, Kushwaha HN, Gautam N, Singh S, Srivastava M, Nath C, Raghubir R, Srivastava AK, Pratap R. Chalcone-based aryloxypropanolamine as a potential antidiabetic and antidyslipidaemic agent. Curr Sci, 2017; 112(8):1675-89. https://doi.org/10.18520/cs/v112/i08/1675-1689

Singh S, Ahmad A, Raghuvanshi DS, Hasanain M, Agarwal K, Dubey V, Fatima K, Alam S, Sarkar J, Luqman S, Khan F, Tandon S, Gupta A. Synthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl) benzopyran-4-one derivatives as anticancer agents. Bioorg Med Chem Lett, 2016; 26(21):5322-7. https://doi.org/10.1016/j.bmcl.2016.09.036

Sun L-P, Jiang Z, Gao L-X, Sheng L, Quan Y-C, Li J, Piao H-R. Synthesis and biological evaluation of furan-chalcone derivatives as protein tyrosine phosphatase inhibitors. Bull Korean Chem Soc, 2013; 34(4):1023- 4. https://doi.org/10.5012/bkcs.2013.34.4.1023

Sun M, Zhang YM, Zhang J, Wang S-C, He L-C. A high expression EGFR/cell membrane chromatography and online high performance liquid chromatography/ mass spectrometry method for screening EGFR antagonists from Rhizoma Polygoni Cuspidati. Acta Pharm Sin B, 2011; 1:115-20. https://doi.org/10.1016/j.apsb.2011.06.008

Tajuddeen N, Isah MB, Suleiman MA, van Heerden FR, Ibrahim MA. The chemotherapeutic potential of chalcones against leishmaniases: a review. Int J Antimicrob Agents, 2018; 51(3):311-18. https://doi.org/10.1016/j.ijantimicag.2017.06.010

Tomar V, Bhattacharjee G, Kamaluddin, Rajakumar S, Srivastava K, Puri SK. Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity. Eur J Med Chem, 2010; 45:745-51. https://doi.org/10.1016/j.ejmech.2009.11.022

Vazquez-Rodriguez S, López RL, Matos MJ, Armesto-Quintas G, Serra S, Uriarte E, Santana L, Borges F, Crego AM, Santos Y. Design, synthesis and antibacterial study of new potent and selective coumarin-chalcone derivatives for the treatment of tenacibaculosis. Bioorg Med Chem, 2015; 23:7045-52. https://doi.org/10.1016/j.bmc.2015.09.028

Venkataramireddy V, Shankaraiah M, Rao AT, Kalyani Ch, Narasu ML, Varala R, Jayashree A. Synthesis and anti-cancer activity of novel 3-aryl thiophene-2-carbaldehydes and their aryl/heteroaryl chalcone derivatives. Rasayan J Chem, 2016; 9(1):31-9.

Venkataramana Reddy PO, Hridhay M, Nikhil K, Khan S, Jha PN, Shah K, Kumar D. Synthesis and investigation into the anticancer and antibacterial activity studies of β-carboline chalcones and their bromide salts. Bioorg Med Chem Lett, 2018; 28:1278-82. https://doi.org/10.1016/j.bmcl.2018.03.033

Wang Y-J, Zhou D-G, He F-C, Chen J-X, Chen Y-Z, Gan X-H, Hu D-Y, Song B-A. Synthesis and antiviral bioactivity of novel chalcone derivatives containing purine moiety. Chin Chem Lett, 2018; 29:127-30. https://doi.org/10.1016/j.cclet.2017.07.006

Wen R, Lv H-N, Jiang Y, Tu P-F. Anti-inflammatory flavone and chalcone derivatives from the roots of Pongamia pinnata (L.) Pierre. Phytochem, 2018; 149:56-63. https://doi.org/10.1016/j.phytochem.2018.02.005

Williams IS, Joshi P, Gatchie L, Sharma M, Satti NK, Vishwakarma RA, Chaudhuri B, Bharate SB. Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatine resistance. Bioorg Med Chem Lett, 2017; 27:3683-7. https://doi.org/10.1016/j.bmcl.2017.07.010

Xi G-L, Liu Z-Q. Coumarin moiety can enhance abilities of chalcones to inhibit DNA oxidation and to scavenge radicals. Tetrahedron, 2014; 70:8397-404. https://doi.org/10.1016/j.tet.2014.08.063

Xu Z, Zhao S, Lv Z, Feng L, Wang Y, Zhang F, Bai L, Deng J. Benzofuran derivatives and their anti-tubercular and anti-bacterial activities. Eur J Med Chem, 2019; 162:266-76. https://doi.org/10.1016/j.ejmech.2018.11.025

Yadav P, Lal K, Kumar A, Guru SK, Jaglan S, Bhushan S. Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles. Eur J Med Chem, 2017; 126:944-53. https://doi.org/10.1016/j.ejmech.2016.11.030

Yu B, Liu H, Kong X, Chen X, Wu C. Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. Eur J Med Chem, 2019; 163:500-11. https://doi.org/10.1016/j.ejmech.2018.12.014

Zheng C-J, Jiang S-M, Chen Z-H, Ye B-J, Piao H-R. Synthesis and anti-bacterial activity of some heterocyclic chalcone derivatives bearing thiofuran, furan and quinoline moieties. Arch Pharm Chem Life Sci, 2011; 344:689-95. https://doi.org/10.1002/ardp.201100005

Zhou D, Xie D, He F, Song B, Hu D. Antiviral properties an interaction of novel chalcone derivatives containing a purine and benzenesulfonamide moiety. Bioorg Med Chem Lett, 2018; 28: 2091-7. https://doi.org/10.1016/j.bmcl.2018.04.042

Zhuang C, Zhang W, Sheng C, Zhang W, Xing C, Miao Z. Chalcone: a privileged structure in medicinal chemistry. Chem Rev, 2017; 117(12):7762-810. https://doi.org/10.1021/acs.chemrev.7b00020

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