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Volume: 9, Issue: 8, August, 2019
DOI: 10.7324/JAPS.2019.90805



Research Article

Formulation and in vitro characterization of anticancer drugs encapsulated chitosan/multi-walled carbon nanotube nanocomposites

Rokaya Aly Sobh, Hanaa El-Sayed Nasr, Wael Sabry Mohamed

  Author Affiliations


Abstract

We aimed to combine the nanoscale structure with bio-molecules to open the door for novel biology and nanotechnology applications. Multi-walled carbon nanotube (MWCNT) was combined with the biocompatible polymer chitosan (Cs) producing the Cs/MWCNT nanocomposite and utilized as a drug carrier for three types of drugs, namely 5-fluorouracil, curcumin, and water-soluble curcumin derivative. The produced nanocomposite was with a homogenous well-defined structure that proved by transmission electronic microscopy, FT-IR, X-ray diffraction, and thermal gravimetric analysis. The results of cytotoxicity assay measurement showed that the curcumin encapsulated Cs or Cs/MWCNT nanocomposite presented higher toxicity towards MCF-7 cancer cells compared with RPE1 normal cells indicating to the selective effectiveness of curcumin nanocomposite towards the destruction of the carcinogenic MCF-7 cells. In vitro release studies showed that Cs/MWCNT nanocomposite possesses better slow controlled release performance than chitosan indicating that there is a strong association between the drug and CNTs which triggers the release of the drug for controlled drug release purposes.

Keywords:

MWCNTs/chitosan nanocomposite, controlled release, anticancer drug.



Citation: Sobh RA, Nasr HE, Mohamed WS. Formulation and in vitro characterization of anticancer drugs encapsulated chitosan/ multi-walled carbon nanotube nanocomposites. J App Pharm Sci 2019; 9(08):032–040.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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