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Volume: 9, Issue: 7, July, 2019
DOI: 10.7324/JAPS.2019.90717



Review Article

Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties

Eric Wei Chiang Chan1, Chen Wai Wong1, Yong Hui Tan1, Jenny Pei Yan Foo1, Siu Kuin Wong2, Hung Tuck Chan3

  Author Affiliations


Abstract

Both resveratrol and pterostilbene are monomeric stilbenes having a 6−2−6 carbon skeleton with two phenyl rings linked by a double-bonded ethylene bridge. Resveratrol has three hydroxyl (−OH) groups, while pterostilbene has two methoxy (–OCH3) groups and one −OH group. They commonly occur in the trans form rather than the cis form. Red grapes and red wines are the main dietary sources of the resveratrol. Pterostilbene occurs in blueberries and grapes. Resveratrol and pterostilbene exhibit many similarities in pharmacological properties, including antioxidant, neuroprotective anti-cancer, cardioprotective, analgesic, anti-atherosclerosis, anti-aging, anti-diabetic, anti-inflammatory, and anti-obesity activities. The stronger pharmacological properties in pterostilbene than resveratrol have been attributed to its two –OCH3 groups. As a result, pterostilbene is more lipophilic which enhances its membrane permeability, bioavailability, and biological potency. Some future studies on resveratrol and pterostilbene are suggested. The sources of information cited in this comparative overview were from Science Direct, Google Scholar, and PubMed.

Keywords:

Resveratrol, pterostilbene, pharmacology, pharmacokinetics, future research.



Citation: Chan EWC, Wong CW, Tan YH, Foo JPY, Wong SK, Chan HT. Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties. J Appl Pharm Sci, 2019; 9(07):124–129.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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