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Volume: 9, Issue: 5, May, 2019
DOI: 10.7324/JAPS.2019.90507



Research Article

Functional properties of glycoside synthesized using polyphenolic extract of Moringa oleifera catalyzed through transglycosylation reaction

Sohaib Nazir, Joko Sulistyo

  Author Affiliations


Abstract

The present study was designed to investigate gallic acid-4-O-β-glucopyranoside (GAGP) in normal and alloxaninduced diabetic rats by a single dose administration of alloxan (150 mg/kg, i.p.). Blood glucose levels measured were significantly (p < 0.05) increasing in all diabetic rats as compared with normal control rats. Three different dosages of GAGP (100, 200, and 400 mg/kg, body weight) showed significantly decreasing (p < 0.05) blood glucose levels of the diabetic rats (66%). All the hyperglycemic groups which were treated with various dosages of GAGP recorded lower biochemical parameters of blood serum as compared with untreated diabetic group. A significant reduction in catalase activity (45%) in lipid peroxidation was observed as compared with normal rats. In contrast, treatment with GAGP restores back near towards normal level (>5%–15%).

Keywords:

Moringa oleifera, transglycosylation, polyphenol glycoside, antioxidant.



Citation: Nazir S, Sulistyo J. Functional properties of glycoside synthesized using polyphenolic extract of Moringa oleifera catalyzed through transglycosylation reaction. J Appl Pharm Sci, 2019; 9(05):058–064.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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