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Volume: 9, Issue: 5, May, 2019
DOI: 10.7324/JAPS.2019.90501

Research Article

Synthesis and biological evaluation of new 2-(4-fluorophenyl) imidazol-5-ones as anticancer agents

Yasmin A. Abo-Elanwar1, Amany S. Mostafa1, Magda A. A. El-Sayed1 2, Magda N. A. Nasr1

  Author Affiliations


Two series of imidazolones were designed, synthesized, and evaluated for their anticancer activity against four cancer cell lines: Hela, MCF-7, PC3, and HCT-116, where four compounds 6, 25, 26, and 29 showed good potency against the whole panel. Compound 30 showed a cytotoxic effect against PC3 cell lines compared to that of the standard doxorubicin with IC50 = 8.15µM, while compounds 4 and 18 showed moderate activity with IC50 range of 10.58–11.45 µM. Enzyme inhibition assay was implemented against CDK2A and VEGFR-2; where varied activities were obtained. Compound 6 exhibited the highest inhibitory activity against VEGFR-2 with an IC50 value of 67 nM and moderate inhibition against CDK2A, while compound 26 achieved the best result against CDK2A with an IC50 value of 0.66 µM.


Imidazlone, chalcones, anticancer, VEGFR-2, CDK2A.

Citation: Abo-Elanwar YA, Mostafa AS, El-Sayed MAA, Nasr MNA. Synthesis and biological evaluation of new 2-(4-fluorophenyl) imidazol-5-ones as Anticancer Agents. J Appl Pharm Sci, 2019; 9(05):001–011.

Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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