Reference

Ataide JA, Cefali LC, Rebelo MdA, Spir LV, Tambourgi EB, Jozala AF, et al. Bromelain loading and release from hydrogel formulated using alginate and arabic gum. Planta Med, 2017; 83:870–6. https://doi.org/10.1055/s-0043-102948 Abdel-Mohzen AM, Aly AS, Hrdina R, Montaser AS, Hebeish A. Eco-synthesis of PVA/chitosan hydrogels for biomedical application. J Polym Environ, 2011; 19:1005–12. https://doi.org/10.1007/s10924-011-0334-0 Banerjee S, Siddiqui L, Bhattacharya S, Kaity S, Ghosh A, Chattopadhyay P, et al. Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application. Int J Biol Macromol, 2010; 50:198–206. https://doi.org/10.1016/j.ijbiomac.2011.10.020 Bernela M, Ahuja M, Thakur R. Enhancement of anti-inflamatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydr Polym, 2016; 143:18–24. https://doi.org/10.1016/j.carbpol.2016.01.055 Budianto E, Muthoharoh SP, Nizardo NM. Effect of crosslinking agents, pH and temperature on swelling behavior of cross-linked chitosan hydrogel. Asian J App Sci, 2015; 3:581–8. Chobotova K, Vernallis AB, Majid FAA. Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives. Cancer Lett, 2010; 290:148–56. https://doi.org/10.1016/j.canlet.2009.08.001 Costa HB, Fernandesa PMB, Romão W, Ventura JA. A new procedure based on column chromatography to purify bromelain by ion exchange plus gel filtration chromatographies. Ind Crops Prod, 2014; 59:163–8. https://doi.org/10.1016/j.indcrop.2014.04.042 Croisfelt F, Martins BC, Rescolino R, Coelho DF, Zanchetta B, Mazzola PG, et al. Poly(N-Isopropylacrylamide)-co-acrylamide hydrogels for the controlled release of bromelain from agroindustrial residues of ananas comosus. Planta Med, 2015; 81:1719–26. https://doi.org/10.1055/s-0035-1557867 Devakate RV, Patil VV, Waje SS, Thorat BN. Purification and drying of bromelain. Sep Purif Technol, 2009; 64:259–64. https://doi.org/10.1016/j.seppur.2008.09.012 Gautam SS, Mishra SK, Dash V, Goyal AK, Rath G. Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant. Thai J Pharma Sci, 2010; 34:67–76. Gonçalves VL, Laranjeira MCM, Fávere VT. Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium. Polímeros Ciência Tecnologia, 2005; 15:6–12. https://doi.org/10.1590/S0104-14282005000100005 Green AA, Hugesh WL. Protein solubility on the basis of solubility in aqueous solutions of salt and organic solvents. Methods Enzymol, 1955; 1:67–90. https://doi.org/10.1016/0076-6879(55)01014-8 Ketnawa S, Chaiwut P, Rawdkuen S. Pineapple wastes: a potential source for bromelain extraction. Food Bioprod Proc, 2012; 90:385–91. https://doi.org/10.1016/j.fbp.2011.12.006 Morris G, Castile J, Smith A, Adams GG, Harding SE. Macromolecular conformation of chitosan in dilute solution: a new global hydrodynamic approach. Carbohydr Polym, 2009; 76:616–21. https://doi.org/10.1016/j.carbpol.2008.11.025 Musfiroh FF, Setiasih S, Handayani S, Hudiyono S, Ilyas NM. In vivo antiplatelet activity aggregation assay of bromelain fractionate by ethanol from extract pineapple core (Ananas comosus [L.] Merr). IOP Conf Ser Mat Sci Eng, 2018; 299:1–4. https://doi.org/10.1088/1757-899X/299/1/012017 Ou A, Bo I. Chitosan hydrogels and their glutaraldehyde-crosslinked counterparts as potential drug release and tissue engineering system-synthesis, characterization, swelling kinetics and mechanism. J Phys Chem Biophys, 2017; 3:1–7. https://doi.org/10.4172/2161-0398.1000256 Reddy GV, Reddy NS, Nagaraja K, Rao KSVK. Synthesis of pH responsive hydrogel matrices from guar gum and poly (acrylamide-co-acrylamidoglycolicacid) for anti-cancer drug delivery. J App Pharm Sci, 2018; 8:84–91. Respati E. Outlook nenas. Pusat Data dan Sistem Informasi Pertanian Sekretariat Jenderal Kementerian Pertanian, Jakarta, Indonesia, 2016. Selvakumaran S, Muhamad II, Razak SI. Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of pore forming agents. Carbohydr Polym, 2016; 135:207–14. https://doi.org/10.1016/j.carbpol.2015.08.051 Setiasih S, Darwis AAC, Dzikria V, Hudiyono S. Stability test of partially purified bromelain from pineapple (Ananas comosus (L.) Merr) core extract in artificial stomatch fluid. IOP Conf Ser Mater Sci Eng, 2018; 299:1–7. Waterborg JH. The lowry method for protein quantitation. In: Walker JM (ed.). The protein protocols handbook second edition. Humana Press, New Jersey, pp 7–9, 2002. https://doi.org/10.1385/1-59259-169-8:7 Yadav HKS, Shivakumar HG. In vitro and in vivo evaluation of pH-sensitive hydrogel of carboxymethyl chitosan for intestinal delivery of theophylline. ISRN Pharm, 2012; 2012(article ID 763127):1–9. Zhao HR, Wang K, Zhao Y, Pan LQ. Novel sustained-release implant of herb extract using chitosan. Biomaterials, 2002; 23:4459–62. https://doi.org/10.1016/S0142-9612(02)00162-X