Research Article | Volume: 8, Issue: 7, July, 2018

Chemical and Cytotoxic Investigation of Non-Polar Extract from Ceiba pentandra (L.) Gaertn.: A Study Supported by Computer Based Screening

Mohamed E. Abouelela,  Mohamed A. A. Orabi,  Reda A. Abdelhamid,  Mohamed S. A. Abdelkader,  Faten M. M. Darwish   
Mohamed E. Abouelela1, Mohamed A. A. Orabi1, Reda A. Abdelhamid1, Mohamed S. A. Abdelkader2, Faten M. M. Darwish3

1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut, Egypt.

2Department of Pharmacognosy, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

3Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Open Access   

Published:  Jul 30, 2018

DOI: 10.7324/JAPS.2018.8710
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Abstract

Nowadays, the discovery of new drugs from natural sources is increasing dramatically. Recently, the sight is directed toward ornamental plants due to their sustainability. In this study, we are reporting on the gas chromatography profile of fatty acids, other related lipids, and hydrocarbons of the non-polar methylene chloride (MC) fraction of the extract of the ornamental tree Ceiba pentandra (L.) Gaertn. Chromatographic purification of the same fraction furnished eight pure known constituents, 3β-taraxerol (1), 3β-taraxerol acetate (2), all-trans-squalene (3), oleic acid (4), 1-hexacosanol (5), β-amyrin (6), β-sitosterol (7) and β-sitosterol-3-O-β-D-glucopyranoside (8), which are relatively abundant in the fraction, six of them are firstly isolated from the plant (1‒6). A computer-based bio-activity study indicated cancer treatment and/or prevention of the isolated compounds (1‒3 and 6) with pa values higher than for the other predicted effects. The experimental cytotoxicity assessment of the MC fraction demonstrated prominent cytotoxic effect against the cancer cell lines HepG2 (IC50 = 14.895 μg/mL) and MCF-7 (IC50 = 18.859 μg/mL).


Keyword:     Ceiba pentandraCytotoxicity TriterpenesSeparation GC-MS PASS.

Citation:

Abouelela ME, Orabi MAA, Abdelhamid RA, Abdelkader MSA, Darwish FMM. Chemical and Cytotoxic Investigation of Non-Polar Extract from Ceiba Pentandra (L.) Gaertn.: A Study Supported by Computer Based Screening. J App Pharm Sci, 2018; 8(07): 057-064.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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