The purpose of this study was to investigate the effect of intensive endurance training on 8-oxoguanine DNA glycosylase (OGG1) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in liver and brain of rats. 16 adult and male albino wistar rats were randomly divided into sedentary control and endurance exercise training groups. Animals ran on treadmill for 6 weeks, 6 days a week, at a speed of 10 m/min (85 percent of maximal oxygen consumption). The content of OGG1 and 8-OHdG were measured using sandwich ELISA assay. Data analyzed using Student’s T-test at P≤0.05 level. Our results showed that intensive endurance training has no significant effect on 8-OHdG contents in liver (t14=1.09, p=0.29) and brain (t14=0.93, p=0.36) of rats. However, contents of OGG1 in liver (t14=5.84, p=0.001) and brain (t14=4.09, p=0.001) of rats significant increases following intensive endurance training. Finally, there were no significantly differences between changes in contents of 8-OHdG (t14=0.44, p=0.66) and OGG1 (t14=1.72, p=0.10) in liver and brain of rats following endurance training. Intensive endurance training maintains 8-OHdG genomic damage in baseline level in liver and brain of rats by increasing contents of OGG1.
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The effect of 8 weeks endurance training and Wild Pistachio supplementation on liver micronutrients in rats
Comparative effect of chronic administration of chloroquine phosphate and methanol extract of Landolphia owariensis on the activities of rat Enzymes
Ilesanmi F F, Balogun E A, Ilesanmi O SEvaluation of Effects of Different Concentrations of Lead, Alcohol and Vitamin E on Protein Carbonyl Content of Brain Tissue in Rats
Anusuya MR, Kiran B