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Volume: 6, Issue: 1, January, 2016
DOI: 10.7324/JAPS.2016.600104

Research Article

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Nurul Iman Aminudin1, Farediah Ahmad1, Muhammad Taher2, Razauden Mohamed Zulkifli3

  Author Affiliations


Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 µg/mL and A-549 at 26.41µg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125µg/mL and 62.5µg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals.


Calophyllum symingtonianum, cytotoxic, antibacterial, coumarin, chromanone acid, Guttiferae.

Citation: Aminudin NI, Ahmad F, Bakhtiar MT, Zulkifli RM. Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum. J App Pharm Sci, 2016; 6 (01): 023-027.

Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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