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Volume: 5, Issue: 3, March, 2015
DOI: 10.7324/JAPS.2015.50308



Research Article

Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn.

Rungrot Cherdtrakulkiat1, Somchai Boonpangrak2, Ratchanok Pingaew3, Supaluk Prachayasittikul4, Somsak Ruchirawat5 6, Virapong Prachayasittikul1

  Author Affiliations


Abstract

Bioactive triterpenoids; 3-acetylaleuritolic acid, stigmasterol, a mixture of triterpenoids, fatty esters and aromatic components were isolated from the aerial parts of Eclipta prostrata by column chromatography. The plant extracts were investigated for their antimicrobial activity (agar dilution method) against twenty-eight strains of gram-positive and gram-negative bacteria, including diploid fungus. In addition, antioxidant and cytotoxic activities were also evaluated. The extracts and isolated fractions exhibited antimicrobial activity against Morexella catarrhalis, Corynebacterium diphtheriae NCTC 10356 and Streptococcus pyogenes with the MIC of 64 µg/mL including Saccharomyces cerevisiae ATCC 2601 (MIC 256 µg/mL). The ethyl acetate extract and isolated fractions displayed antioxidant effect. In addition, the plant extracts showed cytotoxic activity (ED50 > 100 µg/mL) toward HuCCA-1 and KB cells. The results demonstrate beneficial effects of E. prostrata as the antimicrobials and bioactive compounds for medicinal usages.

Keywords:

Eclipta prostrata, Compositae, Bioactive triterpenoids, Antimicrobials, Antioxidants, Cytotoxic activity.



Citation: Rungrot Cherdtrakulkiat, Somchai Boonpangrak, Ratchanok Pingaew Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul. Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn. J App Pharm Sci, 2015; 5 (03): 046-050.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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