Review Article | Volume : 1 Issue : 5, July 2011

Overview of cytokines and receptors in Silicosis

Shambhoo Sharan Tripathi,  Haushila Prasad Pandey,  Bholanath Paul   
Shambhoo Sharan Tripathi1, Haushila Prasad Pandey2, Bholanath Paul1

1Immunobiology Division, Indian Institute of Toxicology Research, Lucknow, India.

2Department of Biochemistry, Banaras Hindu University, Varanasi, India.

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Abstract

Occupational inhalation of crystalline silica for a long period is known to cause silicosis, an irreversible lung damage, often leading to lung fibrosis. It kills thousands of people every year everywhere. The pathophysiology of silicosis involves chronic inflammation of lung due to accumulation of various inflammatory mediators and fibrogenic factors in the airways. In this review we discuss the role of these mediators and their receptors in inducing silicosis and discuss whether inhibitors and decoys can interfere in the induction and onset of the disease.



Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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