Open Access DOI: 10.7324/JAPS.2012.21206
This paper comprises two series of complexes which showed different modes of coordination. The fist series involved an N,N',N''-donor Schiff base ligand from the reaction of 2-acetylpridine as carbonyl compound with N,N'-dimethylethylenediamine (L1), the second series involved N,N',O-donor Schiff base from the condensation reaction of 2-hydroxyacetophenone (ketone) as carbonyl compound with N,N'-dimethylethylenediamine (L2). The ligands and complexes were characterized by using melting point, elemental analysis, FT-IR, NMR, and UV/Visible spectroscopy. The complexes showed very low cytotoxicity towards MCF-7 breast cancer cell line. They also showed moderate zone inhibition against Gram positive bacterium Methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii and Pseudomonas aeruginosa. No antimicrobial activity observed with Klebsiella pneumonia.
Nura Suleiman Gwaram, Hapipah Mohd Ali, Siti Munirah Saharin, Mahmood Ameen Abdulla, Pouya Hassandarvish, Thong Kwai Lin, Chai Lay Ching and Cher Lin Ooi., Synthesis, characterization, and biological applications of some 2- acetylpyridine and acetophenone derivatives. J App Pharm Sci. 2012; 2 (10): 027-038.
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