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Volume: 9, Issue: 2, February, 2019
DOI: 10.7324/JAPS.2019.90217



Short Communication

Qualitative anti-tubercular activity of synthetic ethyl 7-acetyl2-substituted-3-(4-substituted benzoyl) indolizine-1-carboxylate analogues

Sandeep Chandrashekharappa1, Katharigatta N. Venugopala2 & 3, Rashmi Venugopala4, Basavaraj Padmashali1, 5

  Author Affiliations


Abstract

Both the emergence of multidrug-resistant and extensively drug-resistant tuberculosis (TB) are currently the major challenges in the treatment of TB. Only delamanid and bedaquiline have been recently approved as anti-TB drugs in the past 40 years. In an attempt to search for active anti-TB compounds against the sensitive strain of Mycobacterium tuberculosis, H37Rv—a series of synthetic ethyl 7-acetyl-2-substituted-3-(4-substituted benzoyl)indolizine-1- carboxylates (2a–r)—have been screened for in vitro qualitative anti-TB activity using an agar dilution method. It was found that compounds 2a, 2b, 2c, 2f, 2g, 2i, 2j, 2l, 2o, 2p, and 2r, which have various functional groups on the indolizine nucleus, were active against the H37Rv strain.

Keywords:

Indolizine analogs, qualitative screening, agar dilution method, whole cell antitubercular screening, H37Rv strain, Mycobacterium tuberculosis.



Citation: Chandrashekharappa S, Venugopala KN, Venugopala R, Padmashali B. Qualitative anti-tubercular activity of synthetic ethyl 7-acetyl-2-substituted-3-(4-substituted benzoyl) indolizine-1-carboxylate analogs. J Appl Pharm Sci, 2019; 9(02):124–128.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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