Research Article | Volume: 7, Issue: 9, September, 2017

Chemical Composition and Antimicrobial Activity of the Essential Oil of the Leaves of Cupressus macrocarpa Hartweg. ex Gordon

Amal M. Saad,  Magdy M.D. Mohammed,  Mosad A. Ghareeb,  Wafaa S. Ahmed,  ,  Mohamed A. Farid   
Amal M. Saad1, Magdy M.D. Mohammed2, Mosad A. Ghareeb1, Wafaa S. Ahmed1, 3, Mohamed A. Farid4

1Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile, 12661 Warrak El-Hadar, Giza, Egypt.

2Pharmacognosy Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki-12622, Cairo, Egypt.

3Department of Chemistry, College of Science and Arts, Sajir, Shaqra University, Kingdom of Saudi Arabia.

4Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki12622, Cairo, Egypt.

Open Access   

Published:  Sep 30, 2017

DOI: 10.7324/JAPS.2017.70928
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Abstract

Qualitative (GC-MS) and quantitative (GC-FID) analyses of the essential oil (EO) isolated from the leaves of Cupressus macrocarpa revealed the presence of fifteen components, and representing 86.43% of the total oil composition. Their identification was based on their retention times and mass spectral fragmentation patterns. α-terpineol (19.01%), camphenilone (9.78%), elemol (8.92%), 2-tridecanone (8.75%), α-terpinyl acetate (8.62%), 2-pentyl-2-cyclopenten-1-one (6.90%) and β-bisabolol (5.83%) represent major components. Agar diffusion method was conducted to test the antimicrobial activity of the EO against eight pathogenic strains, including gram positive (+ve) and negative (-ve) bacteria and fungi. The obtained results showed inhibition zones with 10.5-21mm diameters, compared to Streptomycin and Nystatin.


Keyword:     Monterey Cypress Cupressaceae Volatile constituents GC/MS GC/FID Antibacterial activity Antifungal activity MIC.

Citation:

Saad AM, Mohammed MMD, Ghareeb MA, Ahmed WS, Farid MA. Chemical Composition and Antimicrobial Activity of the Essential Oil of the Leaves of Cupressus macrocarpa Hartweg. ex Gordon. J App Pharm Sci, 2017; 7 (09): 207-212.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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