Research Article | Volume : 1 Issue : 5, July 2011

Cardioprotective, antioxidant activities and Phytochemical analysis by GC-MS of Gmelina arborea (GA) in Doxorubicin-induced myocardial necrosis in Albino rats

T.Vijay,  M.S. Dhana Rajan,  K.Sarumathy,  S.Palani,  K. Sakthivel   
T.Vijay1, M.S. Dhana Rajan2, K.Sarumathy3, S.Palani4, K. Sakthivel5

1Research and development centre, Bharathiar university, Coimbatore, India, P.G & Research Dept. of Biochemisry, KMG College of Arts & Science, Gudiyattam Vellore dist.,Nadu, India.

2P.G &Research Dept. of Biochemistry, Jaya college of Arts & Science,Tiruninravur, Chennai, India.

3Research and development centre, Bharathiar university, Coimbatore, India bP.G & Research Dept. of Biochemisry, DKM College for Women,

Vellore, India.

4Dept of Biotechnology, Anna Bioresearch Foundation, Arunai Engineering College, Tiruvannamalai, India.

5PG Research, Dept of Zoology, CA Abdul Hakeem College, Melvisharam, Tamil Nadu, India.

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Abstract

Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with Gmelina arborea (Verbenaceae) were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of Gmelina arborea (GA) against DOX- induced cardiotoxicity in rats. GA was given orally to rats(250&500mg/kg) and DOX (20mg/kg) was administered on the seventh day. GA protected against DOX-induced increased the levels of marker enzymes. It significantly inhibited DOX-provoked glutathione (GSH) depletion in cardiac tissues. The reductions of cardiac activities of catalase (CAT) ,superoxide dismutase (SOD) ,glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Pretreatment of GA significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH). GA alleviated histopathological changes in rats’ hearts treated with DOX. In conclusion, GA protects against DOX-induced cardiotoxicity in rats. The study can be attributed, at least in part, to GA’s antioxidant activity.


Keyword:     Cardiotoxicity Doxorubicin antioxidant Gmelina arbore histopathological changes.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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