An efficient method for preparing chalcones, commencing from acetohydrazide and substituted aromatic aldehydes, have been developed. The reaction of acetohydrazide with substituted aldehydes in the presence of ethanol to yield chalcones 4(a-j) and further the compounds thus obtained were identified by IR, 1H NMR and Mass spectral data and have been screened for their anti-cancer and anti-microbial activity. All the compounds shown significant anti-bacterial activity against S. aureus, B. Subtilis, S. typhi and E. coli and potent anti-fungal activity against A. Niger and C. Albicans. Further moderate activity against carcinoma cells.
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Preliminary Anticancer Potency Evaluation and Phytochemical investigation of Methanol Extract of Piper claussenianum (Miq.) C. DC.
Antimicrobial, antioxidant and cytotoxic effects of methanolic extracts of leaves and stems of Glycosmis pentaphylla (Retz.)Md. Amran Howlader, Farhana Rizwan, Shapna Sultana, Mohammad Rakibur Rahman, K. M. Shams-Ud-Doha, Rumana Mowla, Apurba Sarker Apu