Research Article | Volume: 16, Issue: 9, September, 2026

Thai Traditional Polyherbal Infused Oil (T-YaSP) Accelerates Diabetic Wound Healing by Modulating Inflammation and Angiogenesis

Sineenart Sanpinit,  Acharaporn Issuriya,  Oraphan Sakulkeo,  Palika Wetchakul,  Surasak Limsuwan,  Pinanong Na-Phatthalung,  Samuel Abiodun Kehinde,  Siriwan Kantisin,  Jian Tang,  Sasitorn Chusri   

Sineenart Sanpinit1, Acharaporn Issuriya2, Oraphan Sakulkeo3, Palika Wetchakul1, Surasak Limsuwan3, Pinanong Na-Phatthalung4, Samuel Abiodun Kehinde5, Siriwan Kantisin6, Jian Tang7, Sasitorn Chusri5

1Department of Applied Thai Traditional Medicine, School of Medicine, Walailak University, Thasala, Nakhon Si Thammarat, Thailand.

2Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

3Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

4Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

5School of Health Science and Biomedical Technology Research Group, Vulnerable Populations, Mae Fah Luang University, Mueang Chiang Rai, Chiang Rai, Thailand.

6Area-Based Research and Innovation in Cross-Border Health Care Group, Mae Fah Luang University, Chiang Rai, Thailand.

7School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, Nanjing, China.

Open Access   

Published:  Jul 19, 2026

DOI: 10.1177/22313354261461000
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Abstract

Ya-Samarn-Phlae infused oil (T-YaSP) is a traditional Thai polyherbal formulation widely used for the treatment of chronic wounds, including diabetic foot ulcers. Although its clinical efficacy has been reported, the underlying pharmacological mechanisms and the stability of its traditional oil form remain insufficiently characterized. This study aimed to evaluate the anti-inflammatory activity, wound-healing efficacy, and phytochemical stability of T-YaSP. Anti-inflammatory effects were assessed using a carrageenan-induced paw edema model, while wound healing was evaluated in non-diabetic Wistar and diabetic Goto-Kakizaki rats using a full-thickness wound model. Key biomarkers, including vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-β1), and collagen Types I and III, were quantified. A 6-month stability study was conducted to monitor major phytochemical markers (α-mangostin, curcumin, and arecoline). T-YaSP significantly reduced inflammatory mediators like tumor necrosis factor-α, interleukin 1 beta (IL-1β), inducible nitric oxide synthase, and cyclooxygenase-2 and oxidative stress markers like myeloperoxidase and malondialdehyde. Topical application accelerated wound closure in both models, achieving over 90% closure by Day 11. This effect was associated with increased VEGF and TGF-β1 expression and improved collagen remodeling. However, stability analysis revealed significant degradation of key phytochemicals over time. In conclusion, T-YaSP exhibits potent anti-inflammatory and wound-healing activities by modulating inflammatory and angiogenic pathways. However, the instability of its active constituents highlights the need for formulation optimization to ensure consistent therapeutic efficacy.


Keyword:     T-YaSP-infused oil diabetic wounds Goto-Kakizaki rats phytochemical stability traditional Thai medicine dermal remodeling

Citation:

Sanpinit S, Issuriya A, Sakulkeo O, et al. Thai Traditional Polyherbal Infused Oil (T-YaSP) Accelerates Diabetic Wound Healing by Modulating Inflammation and Angiogenesis. J Appl Pharm Sci. 2026;16(9):865-876. https://doi.org/10.1177/22313354261461000

Copyright: © The Author(s). This open-access article is distributed under the Creative Commons Attribution-NonCommercial 4.0 International License, which permits non-commercial use, sharing, adaptation, distribution, and reproduction in any medium or format, provided appropriate credit is given, a link to the license is included, and any changes are indicated.
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