Review Article | Volume: 16, Issue: 8, August, 2026

Ameliorative Role of Novel Dietary Interventions in the Management of Diabetes-associated Metabolic Dysfunction-associated Fatty Liver Disease

Onkar Bedi,  Ashi Mannan,  Varsha Bali,  Shikha Virk,  Moulik Sharma,  Manju Nagpal,  Thakur Gurjeet Singh,  Nirupma Trehanpati,  Pawan Krishan,  Malkiet Kaur,  Gitika Arora Dhingra   

Onkar Bedi1, Ashi Mannan1, Varsha Bali2, Shikha Virk1,3, Moulik Sharma1, Manju Nagpal1, Thakur Gurjeet Singh1, Nirupma Trehanpati4, Pawan Krishan5, Malkiet Kaur6, Gitika Arora Dhingra7

1Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.

2Shivalik College of Pharmacy, Nangal, Punjab, India.

3Chandigarh College of Pharmacy, Landran, Mohali, Punjab, India.

4Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, Delhi, India.

5Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.

6Maharishi Markandeshwar College of Pharmacy, Mullana University, Mullana, Haryana, India.

7SIS University, Nerul (E), Navi Mumbai, Maharashtra, India.

Open Access   

Published:  Jun 29, 2026

DOI: 10.1177/22313354261453149
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Abstract

The progression of various devastating metabolic syndromes like diabetes, metabolic dysfunction-associated fatty liver disease (MAFLD), obesity, etc., is due to the inappropriate lifestyle with respect to the consumption of high-fat and high glycemic index (GI) products. The epidemiological data revealed that the prevalence of metabolic disorders is increasing gradually and will create a global burden. According to reports, the global prevalence of MAFLD in people with Type 2 diabetes mellitus (T2DM) is between 50% and 75%, with 12.5%–87.5% in India. The culprit dietary components, which have a high GI (potatoes, rice, high-sugar beverages, candies and pastries, white bread, etc.), and high-fat diet products (trans fatty acids, sucrose, fructose, high cholesterol, etc.), act significantly in the pathogenesis underlying liver-related complications and further trigger the other secondary metabolic complications. These inappropriate dietary interventions lead to alteration of different pathways like fibroblast growth factor 10 (FGF10), AMP-activated protein kinase (AMPK), c-Jun N-terminal kinase (JNK) pathways, etc., which directly trigger the other secondary pathways leading to diabetes-associated MAFLD and liver-related complications. There are numerous dietary interventions (Vitamin D-rich diet, soy isoflavones, ketogenic diet, unsaturated fatty acid diet, low-carbohydrate diet, green leafy vegetables, etc.), which may improve the various molecular pathways and help in normalizing the pathological state of liver-compromised subjects. In the present review, the new dietary interventions are discussed, which help in managing the diabetes-associated metabolic disorders.


Keyword:     Metabolic dysfunction-associated fatty liver disease (MAFLD) diabetes metabolic syndrome diet intervention clinical evidence

Citation:

Bedi O, Mannan A, Bali V, Virk S, Sharma M, Nagpal M, Singh TG, Trehanpati N, Krishan P, Kaur M, Dhingra GA. Ameliorative Role of Novel Dietary Interventions in the Management of Diabetes-associated Metabolic Dysfunction-associated Fatty Liver Disease. J Appl Pharm Sci. 2026;16(8):546-565. https://doi.org/10.1177/22313354261453149

Copyright: © The Author(s). This open-access article is distributed under the Creative Commons Attribution-NonCommercial 4.0 International License, which permits non-commercial use, sharing, adaptation, distribution, and reproduction in any medium or format, provided appropriate credit is given, a link to the license is included, and any changes are indicated.
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