Research Article | Volume: 16, Issue: 8, August, 2026

Development and Assessment of a Zingiber officinale-based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats

Mabrouka Ghabbari,  Awatef Elwej,  Taysir Ghabbari,  Ghada Ben Salah,  Amal Ahmed Ismail,  Hassane Oudadesse,  Samira Jebahi   

Mabrouka Ghabbari1, Awatef Elwej2,3, Taysir Ghabbari1, Ghada Ben Salah4, Amal Ahmed Ismail5, Hassane Oudadesse6, Samira Jebahi3,7

1Faculty of Sciences of Bizerte, University of Carthage, Bizerte, Tunisia.

2Laboratory of Toxicology and Environmental Health (LR17ES06), Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia.

3Research Laboratory on Energy and Matter for Nuclear Science Development (LR16CNSTN02), National Center for Nuclear Sciences and Technologies, Tunis, Tunisia.

4Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, Saudi Arabia.

5Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi Arabia.

6University of Rennes, CNRS, Rennes, France.

7Higher Institute of Applied Biology of Medenine, University of Gabes, Medenine, Tunisia.

Open Access   

Published:  Jun 18, 2026

DOI: 10.1177/22313354261438281
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Abstract

Diabetic patients exhibit delayed skin wound healing due to chronic hyperglycemia, which results in prolonged tissue recovery. In this work, a skin dressing was synthesized using three natural composites: chitosan, gelatin, and Zingiber officinale herb, commonly known as ginger (CH+GE+ZO). The dressing was applied to albino Wistar rats, which then received an intraperitoneal injection of Alloxan at a dose of 150 mg/kg. Incision caused skin wounds. The antioxidant markers were quantified. A histological study was conducted to evaluate the effectiveness of the skin healing process. Analysis of the oxidative balance revealed a significant (p < .001) increase in enzymatic antioxidant activities in the CH+GE+ZO-treated group compared to the diabetic group. A considerable increase in non-enzymatic markers was observed compared to the diabetic group (p < .001). Histologically, the application of a composite synthesized by CH+GE+ZO dressing showed an improvement in the healing process, compared to controls, and a total recovery of wounds was observed around Day 13. This was characterized by a progressive reepithelialization, a structured organization of the layers of the epidermis, as well as a partial restoration of the cutaneous appendages. Overall, the synthesized biological dressing actively contributes to tissue repair and skin healing.


Keyword:     Healing diabetes wounds phytotherapy Z. officinale dressing

Citation:

Ghabbari M, Elwej A, Ghabbari T, Ben Salah G, Ismail AA, Oudadesse H, Jebahi S. Development and Assessment of a Zingiber officinale-based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats. J Appl Pharm Sci. 2026;16(8):710-722. https://doi.org/10.1177/22313354261438281

Copyright: © The Author(s). This open-access article is distributed under the Creative Commons Attribution-NonCommercial 4.0 International License, which permits non-commercial use, sharing, adaptation, distribution, and reproduction in any medium or format, provided appropriate credit is given, a link to the license is included, and any changes are indicated.
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