Review Article | Volume: 16, Issue: 6, June, 2026

Enhancing Pharmacy Practice: Role of Clinical Decision Support System in Mitigating Drug-related Problems

Savera Arain,  Shabeer Ali Thorakkattil,  Mohammed Alzaylaee,  Suhaj Abdulsalim,  Mohammed Salim Karattuthodi,  Prashant Chandra,  Mahmathi Karuppannan,  Mazhuvanchery Kesavan Unnikrishnan   

Savera Arain1, Shabeer Ali Thorakkattil1,2, Mohammed Alzaylaee1, Suhaj Abdulsalim3, Mohammed Salim Karattuthodi4, Prashant Chandra5, Mahmathi Karuppannan2, Mazhuvanchery Kesavan Unnikrishnan5

1Pharmacy Services Department, Johns Hopkins Aramco Healthcare (JHAH), Dhahran, Eastern Province, Saudi Arabia.

2Department of Pharmacy Practice and Clinical Pharmacy, Faculty of  Pharmacy, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor, Malaysia.

3Department of Pharmacy Practice, College of Pharmacy, Qassim University, Buraydah, Al Qassim, Saudi Arabia.

4Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.

5Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita  Vishwa Vidyapeetham, Kochi, Kerala, India.

Open Access   

Published:  Apr 02, 2026

DOI: 10.1177/22313354261427939
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Abstract

Drug-related problems (DRPs) significantly impact patients’ medication therapy outcomes. These include adverse drug reactions, ineffective drug therapy, excessive or sub-therapeutic drug dosage, development of drug resistance, drug–drug interactions, medication errors, and medication non-adherence. A clinical decision support system (CDSS) helps mitigate DRPs by providing clinical suggestions and reminders that enable decision-making by pharmacists and clinicians toward improving the overall well-being of patients. CDSS, associated with pharmacy services, enable pharmacists to consider substitutes for specific medications and address specific health problems by providing medication therapy management (MTM), acute pain management and other related services. Our research focused on identifying the benefits of CDSS integration in the pharmacist workflow toward managing DRPs. We conducted a thorough search across major databases, Scopus, Embase, PubMed, and Google Scholar, to obtain appropriate articles published through November 2025 and selected articles that met the inclusion criteria. Some of the challenges in CDSS implementation identified were integration issues with existing electronic health records (EHRs), incompatibility with current workflows, costs, inadequate leadership, and poor data quality.


Keyword:     Drug-related problems clinical decision support system medication safety electronic health records patient safety

Citation:

Arain S, Thorakkattil SA, Alzaylaee M, Abdulsalim S, Karattuthodi MS, Chandra P, Karuppannan M, Unnikrishnan MK. Enhancing Pharmacy Practice: Role of Clinical Decision Support System in Mitigating Drug-related Problems. J Appl Pharm Sci. 2026;16(6):103-111. https://doi.org/10.1177/22313354261427939

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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